Weeds within the seedline area and in close proximity to crop seedlings are highly competitive and reduce crop yield. When chemically selective herbicides are unavailable or ineffective, spatially selective removal is required and is often a manual operation. Automation of selective weed removal requires sensing and actuation systems. Image and spectral analysis can discriminate weeds from crop plants while precise dosing methods are required for automated treatment of Small. distinct weeds. A pulsed-jet, micro-dosing actuator was developed to apply liquid herbicide treatments. Vie biological performance of micro-dosing was evaluated infield-grown processing tomatoes with a nonselective herbicide (glyhosate) in mixtures including surfactants and splash-inhibiting polymers. Liquid dose rates were 37 muL/cm(2) for treatment areas of 6.3 x 12.5 mm. Pulse durations were 6 to 10 ins. A formulation including a surfactant and a polymer provided efficacy, while reducing splash, i.e., "micro-drift" that caused phytotoxicity to adjacent crop plants. When treated with the micro-dosing system, splash-related phytotoxicity produced greater yield suppression than competition from escaped weeds. The results established that use of non-selective herbicides for micro-scale dosing of weeds during early crop growth is a feasible alternative to broadcast application of chemically-selective herbicides. The optimal point of crop and weed growth for using a weed-sensing, one-pass post-emergent control system requires understanding of crop development. weed competition, and the ability of the crop to recover from inadvertent splash of micro-dosed materials.