International consensus report on the investigation and management of primary immune thrombocytopenia

被引：1351

作者：

Provan, Drew ^{[1
]}

Stasi, Roberto ^{[2
]}

Newland, Adrian C. ^{[1
]}

Blanchette, Victor S. ^{[3
]}

Bolton-Maggs, Paula ^{[4
]}

Bussel, James B. ^{[5
]}

Chong, Beng H. ^{[6
]}

Cines, Douglas B. ^{[7
]}

Gernsheimer, Terry B. ^{[8
,9
]}

Godeau, Bertrand ^{[10
]}

Grainger, John ^{[11
]}

Greer, Ian ^{[12
]}

Hunt, Beverley J. ^{[13
,14
,15
,16
]}

Imbach, Paul A. ^{[17
]}

Lyons, Gordon ^{[18
]}

McMillan, Robert ^{[19
]}

Rodeghiero, Francesco ^{[20
]}

Sanz, Miguel A. ^{[21
]}

Tarantino, Michael ^{[22
]}

Watson, Shirley ^{[23
]}

Young, Joan ^{[24
]}

Kuter, David J. ^{[25
,26
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Dept Haematol, London E1 2ES, England

[2] NHS Trust, St Georges Healthcare, Dept Haematol, London, England

[3] Univ Toronto, Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[4] Manchester Royal Infirm, Dept Clin Haematol, Manchester M13 9WL, Lancs, England

[5] New York Hosp, Dept Pediat, New York, NY 10021 USA

[6] Univ New S Wales, St George Clin Sch, Sydney, NSW, Australia

[7] Hosp Univ Penn, Dept Pathol & Lab, Philadelphia, PA 19104 USA

[8] Puget Sound Blood Ctr, Seattle, WA 98104 USA

[9] Univ Washington, Seattle, WA 98195 USA

[10] Assistance Publ Hop Paris, Serv Med Interne, Paris, France

[11] Royal Manchester Childrens Hosp, Manchester M27 1HA, Lancs, England

[12] Univ York, Hull York Med Sch, York YO10 5DD, N Yorkshire, England

[13] Kings Coll London, London WC2R 2LS, England

[14] Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Dept Haematol, London, England

[15] Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Dept Pathol, London, England

[16] Guys & St Thomas Natl Hlth Serv NHS Fdn Trust, Dept Rheumatol, London, England

[17] Univ Childrens Hosp, Basel, Switzerland

[18] St James Univ Hosp, Leeds LS9 7TF, W Yorkshire, England

[19] Scripps Res Inst, La Jolla, CA 92037 USA

[20] San Bortolo Hosp, Dept Cell Therapy & Hematol, Vicenza, Italy

[21] Hosp Univ La Fe, Dept Haematol, Valencia, Spain

[22] Comprehens Bleeding Disorders Ctr, Peoria, IL USA

[23] ITP Support Assoc, Bedford, England

[24] Platelet Disorder Support Assoc, Rockville, MD USA

[25] Massachusetts Gen Hosp, Dept Hematol, Boston, MA 02114 USA

[26] Harvard Univ, Sch Med, Boston, MA USA

来源：

BLOOD | 2010年 / 115卷 / 02期

关键词：

INTRAVENOUS ANTI-D; HIGH-DOSE DEXAMETHASONE; QUALITY-OF-LIFE; THROMBOPOIESIS-STIMULATING PEPTIBODY; ANTI-CD20; MONOCLONAL-ANTIBODY; BONE-MARROW EXAMINATION; FETAL PLATELET COUNTS; LONG-TERM OUTCOMES; PURPURA ITP; ADULT PATIENTS;

D O I：

10.1182/blood-2009-06-225565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Previously published guidelines for the diagnosis and management of primary immune thrombocytopenia (ITP) require updating largely due to the introduction of new classes of therapeutic agents, and a greater understanding of the disease pathophysiology. However, treatment-related decisions still remain principally dependent on clinical expertise or patient preference rather than high-quality clinical trial evidence. This consensus document aims to report on new data and provide consensus-based recommendations relating to diagnosis and treatment of ITP in adults, in children, and during pregnancy. The inclusion of summary tables within this document, supported by information tables in the online appendices, is intended to aid in clinical decision making. (Blood. 2010; 115:168-186)

引用

页码：168 / 186

页数：19

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