Lewis Acid Catalyzed Friedel-Crafts Alkylation of Alkenes with Trifluoropyruvates

被引：27

作者：

Xiang, Bin ^{[1
]}

Xu, Teng-Fei ^{[1
]}

Wu, Liang ^{[1
]}

Liu, Ren-Rong ^{[1
]}

Gao, Jian-Rong ^{[1
]}

Jia, Yi-Xia ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 09期

基金：

中国国家自然科学基金;

关键词：

CARBONYL-ENE REACTIONS; ENANTIOSELECTIVE CONSTRUCTION; CONJUGATE ADDITION; TERTIARY ENAMIDES; ACCESS; GLYOXYLATE; BEARING; ALKENYLATION; EFFICIENT; INDOLES;

D O I：

10.1021/acs.joc.6b00358

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Friedel-Crafts alkylation reaction of styrenes with trifluoropyruvates has been developed, which delivered allylic alcohols in excellent yields (up to 98%) using the Ni(ClO4)(2)center dot 6H(2)O/bipyridine complex as a catalyst. The asymmetric reaction was catalyzed by the chiral Cu(OTf)(2)/bisoxazoline complex to afford the corresponding chiral allylic alcohols bearing trifluoromethylated quaternary stereogenic centers in moderate enantioselectivities (up to 75% ee).

引用

页码：3929 / 3935

页数：7

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