Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

被引：25
作者：
Weidt, Stefan K. [1 ]
Mackay, C. Logan [1 ]
Langridge-Smith, Pat R. R. [1 ]
Sadler, Peter J. [1 ]
机构：
[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland
来源：
CHEMICAL COMMUNICATIONS | 2007年 / 17期
关键词：
D O I：
10.1039/b701903c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The high mass accuracy of FT-ICR MS combined with N-15-labelling shows that mono- and di- platinated products from the reaction of erythrocyte superoxide dismutase with the anticancer drug cisplatin in solution retain their ammine ligands, in contrast to a recent X-ray crystallographic study.
引用
收藏
页码：1719 / 1721
页数：3
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