Antibacterial activity of Mannich bases derived from 2-naphthols, aromatic aldehydes and secondary aliphatic amines

被引：16
|
作者：
Roman, Gheorghe [1 ]
Nastasa, Valentin [2 ]
Bostanaru, Andra-Cristina [2 ]
Mares, Mihai [2 ]
机构：
[1] Petru Poni Inst Macromol Chem, 41A Aleea Gr Ghica Voda, Iasi 700487, Romania
[2] Ion Ionescu de la Brad Univ, Lab Antimicrobial Chemotherapy, 8 Aleea Sadoveanu, Iasi 700489, Romania
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 10期
关键词：
Aminomethylation; Mannich base; Thiophene; Antibacterial; MRSA; AMINOALKYLATION; CHEMISTRY; EPIDEMIOLOGY; DERIVATIVES; NAPHTHOLS;
D O I：
10.1016/j.bmcl.2016.03.098
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A small library of 1-aminoalkyl 2-naphthols has been synthesized through the direct Mannich reaction of 2-naphthols with (hetero)aromatic aldehydes and secondary amines. All of the Mannich bases having a thiophen-2-yl ring in their structure had good activity against Gram-positive bacteria, irrespective of the nature of the amino moiety. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2498 / 2502
页数：5
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