Background & aims: Aggressive behavior (AB) progress to a major concern among adolescents. The present study is designed to assess possible association between dietary intake of macronutrient, some micronutrient, cholesterol, and antioxidants with AB in adolescent girls, from age 9-13 years old. Materials and methods: In the case-control study, a total 212 primary school girls between 9 and 13 years of age were divided into two groups (106 with AB and 106 healthy) base on aggression score of the Buss-Perry questionnaire. A 147-item food frequency questionnaire (FFQ) was used to evaluate nutritional intake of subjects. Independent t-test and Mann-Whitney test was used to compare quantitative variables between the two groups according to the normality of data distribution. Chi-square test was used to compare categorical variables between case and control groups. Logistic regression models were used to assess possible association of nutrients intake with AB. Results: The consumption of more simple carbohydrate [odds ratios (OR): 14.53, confidence interval (CI): (13.23, 17.56)] total fat [OR: 13.31, CI: (8.50, 16.47)], SFAs [OR: 11.831, CI: (8.94, 15.36)], TFAs [OR: 9.10, CI: (6.87, 10.12)], and caffeine [OR: 16.26, CI: (14.53, 17.88)] significantly increase the occurrence of aggressive behaviors. Conversely, intake of fiber [OR: 0.997, CI: (0.012, 0.999)], W3 [OR: 0.991, CI: (0.040, 0.999)], and vitamin K [OR: 0.994, CI: (0.990, 0.999)] were marginal associated with reduced odds of AB. Conclusions: The intake of caffeine, simple carbohydrate, total fat, SFAs, TFAs, could increase the occurrence of AB. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.