Papillary Thyroid Carcinoma with Brain Metastases: An Unusual 10-Year-Survival Case

被引:11
|
作者
Miranda, Elizabete R. [1 ]
Padrao, Eduardo L. [2 ]
Silva, Barbara C. [1 ,3 ]
De Marco, Luiz [3 ]
Sarquis, Marta S. [1 ]
机构
[1] Univ Fed Minas Gerais, Dept Med, BR-30140060 Belo Horizonte, MG, Brazil
[2] Hosp Biocor, Nucl Med Unit, Belo Horizonte, MG, Brazil
[3] Univ Fed Minas Gerais, Dept Surg, BR-30140060 Belo Horizonte, MG, Brazil
关键词
DISTANT METASTASES; CANCER; THERAPY; GLAND;
D O I
10.1089/thy.2009.0442
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy with indolent clinical course and good prognosis. Brain metastases are extremely rare and the average survival time after diagnosis has been reported to be around 12 months. Summary: We here report a 69-year-old patient who was admitted to the emergency room in January 2000 with progressive dizziness, headache, and vomiting. Five years before admission the patient underwent partial thyroidectomy for goiter. On admission, a diagnostic evaluation that included brain magnetic resonance imaging showed multiple brain lesions, and a stereotactic biopsy demonstrated a metastatic carcinoma from primary PTC, with the neoplastic cells staining for thyroglobulin. Total thyroidectomy was then performed, which showed colloid goiter and a PTC metastasis on a cervical lymph node. The patient received 200 mCi of radioactive iodine (131 I) with suppressive therapy with l-thyroxine thereafter. Subsequently, serial whole-body scanning and magnetic resonance imaging showed multiple brain metastases and the patient received further I-131 treatment, with a total dose of 1.2 Ci in a 10-year span. She also underwent partial surgical resection of brain metastases because complete resection was not feasible. Thereafter, the patient was subjected to whole-brain body radiotherapy with a dose of 44 Gy, followed by two brain gamma knife radiosurgeries (15 Gy each). To date, biochemical tests are within the normal range and the patient remains asymptomatic. Conclusions: To our knowledge, this is the first report of a 10-year-survival case of brain metastases from PTC, despite this being a bad prognostic factor. A combined approach of surgical excision, 131 I, whole-brain radiotherapy, and gamma knife radiosurgery was successful to treat metastases derived from primary tumor.
引用
收藏
页码:657 / 661
页数:5
相关论文
共 50 条
  • [1] Ten-year survival in thyroid papillary carcinoma with brain metastases
    De Marco, Luiz
    Miranda, Elizabete
    Padrao, Eduardo L.
    Sarquis, Marta S.
    ENDOCRINE JOURNAL, 2010, 57 : S456 - S456
  • [2] Unusual brain metastases from papillary thyroid carcinoma: Case report
    Aguiar, PH
    Agner, C
    Tavares, FR
    Yamaguchi, N
    NEUROSURGERY, 2001, 49 (04) : 1008 - 1013
  • [3] Unusual brain metastases from papillary thyroid carcinoma: Case report - Comments
    Rock, JP
    Gabikian, P
    Brem, H
    Sawaya, R
    NEUROSURGERY, 2001, 49 (04) : 1013 - 1013
  • [4] An unusual case of papillary carcinoma of the thyroid with cutaneous and breast metastases only
    Loureiro, MM
    Leite, VH
    Boavida, JM
    Raposo, JF
    Henriques, MM
    Limbert, ES
    Sobrinho, LG
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1997, 137 (03) : 267 - 269
  • [5] Unusual Case of Adrenal and Renal Metastases From Papillary Carcinoma of Thyroid
    Malhotra, Gaurav
    Upadhye, Trupti S.
    Sridhar, Epari
    Asopa, Ramesh V.
    Garde, Parul S.
    Gawde, Sachin
    Rangarajan, Venkatesh
    CLINICAL NUCLEAR MEDICINE, 2010, 35 (09) : 731 - 736
  • [6] CASE-REPORT - BRAIN METASTASES FROM PAPILLARY CARCINOMA THYROID
    JYOTHIRMAYI, R
    EDISON, J
    NAYAR, PP
    NAIR, MK
    RAJAN, B
    BRITISH JOURNAL OF RADIOLOGY, 1995, 68 (811): : 767 - 769
  • [7] Unusual metastases of papillary thyroid carcinoma: report of 2 cases
    Angeles-Angeles, Arturo
    Chable-Montero, Fredy
    Martinez-Benitez, Braulio
    Albores-Saavedra, Jorge
    ANNALS OF DIAGNOSTIC PATHOLOGY, 2009, 13 (03) : 189 - 196
  • [8] BRAIN METASTASES FROM PAPILLARY THYROID-CARCINOMA
    HAY, ID
    ARCHIVES OF INTERNAL MEDICINE, 1987, 147 (03) : 607 - 607
  • [9] An unusual case of medullary thyroid carcinoma mimicking papillary thyroid carcinoma
    Mundim, F.
    Serrano, C.
    Mundim, P.
    Diniz, R.
    Jorge, L.
    Romero, R.
    Pelizzaro, R.
    Filho, T.
    Sousa, N.
    VIRCHOWS ARCHIV, 2021, 479 : S233 - S233
  • [10] An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report
    Alamdari, Manouchehr Iranparvar
    Habibzadeh, Afshin
    Pakrouy, Hossein
    Chaichi, Parastoo
    Sheidaei, Sharareh
    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS, 2018, 51 : 218 - 220