R/qtl: QTL mapping in experimental crosses

被引：2656

作者：

Broman, KW

Wu, H

Sen, S

Churchill, GA

机构：

[1] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA

[2] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

BIOINFORMATICS | 2003年 / 19卷 / 07期

关键词：

D O I：

10.1093/bioinformatics/btg112

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

R/qtl is an extensible, interactive environment for mapping quantitative trait loci (QTLs) in experimental populations derived from inbred lines. It is implemented as an add-on package for the freely-available statistical software, R, and includes functions for estimating genetic maps, identifying genotyping errors, and performing single-QTL and two-dimensional, two-QTL genome scans by multiple methods, with the possible inclusion of covariates.

引用

页码：889 / 890

页数：2

共 11 条

[1] A MAXIMIZATION TECHNIQUE OCCURRING IN STATISTICAL ANALYSIS OF PROBABILISTIC FUNCTIONS OF MARKOV CHAINS [J].

BAUM, LE ;

PETRIE, T ;

SOULES, G ;

WEISS, N .

ANNALS OF MATHEMATICAL STATISTICS, 1970, 41 (01) :164-&

[2]

CHURCHILL GA, 1994, GENETICS, V138, P963

[3] MAXIMUM LIKELIHOOD FROM INCOMPLETE DATA VIA EM ALGORITHM [J].

DEMPSTER, AP ;

LAIRD, NM ;

RUBIN, DB .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-METHODOLOGICAL, 1977, 39 (01) :1-38

[4] A SIMPLE REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI IN LINE CROSSES USING FLANKING MARKERS [J].

HALEY, CS ;

KNOTT, SA .

HEREDITY, 1992, 69 :315-324

[5]

Ihaka R., 1996, J COMPUTATIONAL GRAP, V5, P299, DOI [DOI 10.1080/10618600.1996.10474713, 10.1080/10618600.1996.10474713, 10.2307/1390807]

[6]

Kao CH, 1999, GENETICS, V152, P1203

[7]

LANDER E S, 1987, Genomics, V1, P174, DOI 10.1016/0888-7543(87)90010-3

[8]

LANDER ES, 1989, GENETICS, V121, P185

[9] Map manager QTX, cross-platform software for genetic mapping [J].

Manly, KF ;

Cudmore, RH ;

Meer, JM .

MAMMALIAN GENOME, 2001, 12 (12) :930-932

[10]

Sen S, 2001, GENETICS, V159, P371

← 1 2 →