Sharpless asymmetric dihydroxylation on an industrial scale

被引：49
|
作者：
Ahrgren, L [1 ]
Sutin, L [1 ]
机构：
[1] Pharmacia & Upjohn AB, S-75182 Uppsala, Sweden
来源：
ORGANIC PROCESS RESEARCH & DEVELOPMENT | 1997年 / 1卷 / 06期
关键词：
D O I：
10.1021/op970030v
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
It is shown in this study that the inexpensive N-methylmorpholine N-oxide can be successfully employed as a reoxidant in the Sharpless asymmetric dihydroxylation reaction on a large scale, The reaction of o-isopropoxy-m-methoxystyrene on a 2 kg scale gave the corresponding diol in high yield and high enantiomeric excess. The extension of this synthetic method to other olefins is also presented.
引用
收藏
页码：425 / 427
页数：3
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