Rapid access to acyclic nucleosides via conjugate addition

被引：36
|
作者：
Guillarme, S
Legoupy, S
Aubertin, AM
Olicard, C
Bourgougnon, N
Hueta, F
机构：
[1] Univ Maine, Fac Sci & Tech, UMR CNRS 6011, Organ Synth Lab, F-72085 Le Mans 9, France
[2] Univ Strasbourg, INSERM U544, Fac Med, Inst Virol, F-67000 Strasbourg, France
[3] Ctr Rech & Enseignement Yves Coppens, Lab Biol & Chim Mol, F-56017 Vannes, France
来源：
TETRAHEDRON | 2003年 / 59卷 / 12期
关键词：
Michael addition; acyclic nucleosides; deaza purine and deaza pyrimidine; analogs of penciclovir;
D O I：
10.1016/S0040-4020(03)00190-X
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of several acyclic nucleosides 5 and 6, analogs of penciclovir, was achieved by Michael addition as the key step. This reaction worked not only for the protected natural bases but even for the less nucleophilic deaza purine and deaza pyrimidine. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2177 / 2184
页数：8
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