Epigenetic mechanisms of breast cancer: an update of the current knowledge

被引：0
|
作者：
Karsli-Ceppioglu, Seher [1 ,2 ,3 ]
Dagdemir, Aslihan [1 ,2 ]
Judes, Gaelle [1 ,2 ]
Ngollo, Marjolaine [1 ,2 ]
Penault-Llorca, Frederique [1 ,2 ]
Pajon, Amaury [1 ,2 ]
Bignon, Yves-Jean [1 ,2 ]
Bernard-Gallon, Dominique [1 ,2 ]
机构：
[1] Ctr Jean Perrin CBRV, Dept Oncogenet, F-63000 Clermont Ferrand, France
[2] EA 4677 ERTICA Univ Auvergne, F-63000 Clermont Ferrand, France
[3] Marmara Univ, Dept Toxicol, Fac Pharm, Istanbul, Turkey
来源：
EPIGENOMICS | 2014年 / 6卷 / 06期
关键词：
BRCA1; breast cancer; DNA methylation; epigenetics; epigenetic therapy; estrogen; EZH2; histone modification; BRCA1 PROMOTER METHYLATION; ESTROGEN-RECEPTOR EXPRESSION; CPG ISLAND HYPERMETHYLATION; TUMOR-SUPPRESSOR GENES; PERIPHERAL-BLOOD CELLS; SPORADIC BREAST; DNA METHYLATION; HISTONE MODIFICATIONS; ABERRANT METHYLATION; DE-NOVO;
D O I：
10.2217/EPI.14.59
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Epigenetic alterations are heritable changes in gene expression that occur without causing any change in DNA sequence. They are important key factors for cancer development and prognosis. Breast cancer is induced by the accumulation of altered gene regulation. Besides genetic mutations, epigenetics mechanisms have an important role in breast cancer tumorigenesis. Investigations related with aberrant epigenetic regulations in breast cancer focus on initiating molecular mechanisms in cancer development, identification of new biomarkers to predict breast cancer aggressiveness and the potential of epigenetic therapy. In this review, we will summarize the recent knowledge about the role of epigenetic alterations related with DNA methylation and histone modification in breast cancer. In addition, altered regulation of breast cancer specific genes and the potential of epigenetic therapy will be discussed according to epigenetic mechanisms.
引用
收藏
页码：651 / 664
页数：14
相关论文
共 50 条
  • [1] Stress and breast cancer: a systematic update on the current knowledge
    Naja Rod Nielsen
    Morten Grønbæk
    Nature Clinical Practice Oncology, 2006, 3 : 612 - 620
  • [2] Stress and breast cancer:: a systematic update on the current knowledge
    Nielsen, Naja Rod
    Gronbaek, Morten
    NATURE CLINICAL PRACTICE ONCOLOGY, 2006, 3 (11): : 612 - 620
  • [3] Current insights into the epigenetic mechanisms of skin cancer
    Sang, Yanqi
    Deng, Yu
    DERMATOLOGIC THERAPY, 2019, 32 (04)
  • [4] Epigenetic mechanisms in breast cancer therapy and resistance
    Garcia-Martinez, Liliana
    Zhang, Yusheng
    Nakata, Yuichiro
    Chan, Ho Lam
    Morey, Lluis
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [5] Epigenetic mechanisms in breast cancer therapy and resistance
    Liliana Garcia-Martinez
    Yusheng Zhang
    Yuichiro Nakata
    Ho Lam Chan
    Lluis Morey
    Nature Communications, 12
  • [6] The impact of epigenetic mechanisms in migraine: Current knowledge and future directions
    Gallardo, Victor Jose
    Vila-Pueyo, Marta
    Pozo-Rosich, Patricia
    CEPHALALGIA, 2023, 43 (02)
  • [7] An update on epigenetic mechanisms in endometriosis
    Le, Kyle N.
    Benor, Ariel
    Decherney, Alan
    MINERVA OBSTETRICS AND GYNECOLOGY, 2024,
  • [8] β-Catenin in oral cancer: An update on current knowledge
    Gonzalez-Moles, M. A.
    Ruiz-Avila, I.
    Gil-Montoya, J. A.
    Plaza-Campillo, J.
    Scully, C.
    ORAL ONCOLOGY, 2014, 50 (09) : 818 - 824
  • [9] EPIGENETIC CHANGES IN BREAST CANCER AND OVARIAN CANCER PART I MECHANISMS OF EPIGENETIC CHANGES
    Nowak, Ewa
    Wasinska, Magdalena
    Bednarek, Ilona
    POSTEPY BIOLOGII KOMORKI, 2017, 44 (03) : 301 - 312
  • [10] Breast cancer update -: analysis of knowledge of Brazilian breast surgeons
    Sahium de Almeida, R. Cecilio
    Novita, G.
    Codarin, R. R.
    Ruiz, C. A.
    Nazario, A. C. P.
    Santos, C. C.
    Carelli Filho, I.
    Borges, J. B. R.
    Oliveira Filho, H. R.
    del Grossi, L. P.
    EJC SUPPLEMENTS, 2008, 6 (07): : 58 - 58
12345