The control of cardiac ventricular excitability by autonomic pathways
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作者:
Finlay, Malcolm
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Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, EnglandBarts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, England
Finlay, Malcolm
[1
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Harmer, Stephen C.
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Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, EnglandBarts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, England
Harmer, Stephen C.
[1
]
Tinker, Andrew
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Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, EnglandBarts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, England
Tinker, Andrew
[1
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[1] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, Heart Ctr, Charterhouse Sq, London EC1M 6BQ, England
Central to the genesis of ventricular cardiac arrhythmia are variations in determinants of excitability. These involve individual ionic channels and transporters in cardiac myocytes but also tissue factors such as variable conduction of the excitation wave, fibrosis and source-sink mismatch. It is also known that in certain diseases and particularly the channelopathies critical events occur with specific stressors. For example, in hereditary long QT syndrome due to mutations in KCNQI arrhythmic episodes are provoked by exercise and in particular swimming. Thus not only is the static substrate important but also how this is modified by dynamic signalling events associated with common physiological responses. In this review, we examine the regulation of ventricular excitability by signalling pathways from a cellular and tissue perspective in an effort to identify key processes, effectors and potential therapeutic approaches. We specifically focus on the autonomic nervous system and related signalling pathways. (C) 2017 Elsevier Inc All rights reserved.
机构:
Harbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150086, Heilongjiang, Peoples R China
Harbin Med Univ, Cardiovasc Res Inst, Harbin 150086, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150086, Heilongjiang, Peoples R China
Yang, Baofeng
Lu, Yanjie
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Harbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150086, Heilongjiang, Peoples R China
Harbin Med Univ, Cardiovasc Res Inst, Harbin 150086, Heilongjiang, Peoples R ChinaHarbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150086, Heilongjiang, Peoples R China
Lu, Yanjie
Wang, Zhiguo
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Harbin Med Univ, Cardiovasc Res Inst, Harbin 150086, Heilongjiang, Peoples R China
Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada
Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, CanadaHarbin Med Univ, Dept Pharmacol, State Prov Key Labs Biomed Pharmaceut China, Harbin 150086, Heilongjiang, Peoples R China