Design, installation and commissioning of Indonesia INDRAMAYU 2 x 4,500 m(3)/d low-temperature multi-effect desalination plant were concerned in this paper. The process modeling, design parameters and commissioning results were emphatically stated definitely. Professional collaborative design and 3D visual design were conducted using the software of PDMS, Inventor and Promis-E. The desalination device was composed of seven-effect evaporators and a condenser with a total length of 56 m. The gain output ratio of the system was increased more than 10% than seven-effect multi-effect distillation thermal vapor compression desalination process published in former literature. Equipment installation method was also described explicitly. The debugging results show that design parameter selection for process calculation model is reasonable.