Genetic control of delayed-type hypersensitivity to gold antigens in mice

The genetic control of delayed-type hypersensitivity (DTH) to both gold(I) and gold(III) antigens was investigated in various strains of mice. Most mouse strains, with the exception of those with the major histocompatibility complex I-A(b) allele, showed a marked DTH response to each antigen; the magnitude of the response to gold(III) was greater than that of the response to gold(I). Moreover, the high responsive trait was dominant. The DTH footpad response was mediated by CD4(+)8(-), Ia(-) T cells. However, CD8(+) T cells did not suppress footpad swelling. These results indicate that gold(I) and gold(III) can both stimulate a DTH response in mice. (C) 1998 Elsevier Science Ireland Ltd.