Hydrogen sulfide in stroke: Protective or deleterious? (Reprinted from Neurochemistry International vol 105, pg 1-10, 2017)

被引：8

作者：

Chan, Su Jing ^{[1
,2
,3
]}

Wong, Peter T. -H. ^{[4
]}

机构：

[1] ASTAR, Inst Med Biol, Singapore, Singapore

[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Charlestown, MA 02129 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, 16 Med Dr,04-01, Singapore 117600, Singapore

来源：

NEUROCHEMISTRY INTERNATIONAL | 2017年 / 107卷

基金：

新加坡国家研究基金会;

关键词：

Hydrogen sulphide; Stroke; Toxic effect; Neuroprotection; CYSTATHIONINE-BETA-SYNTHASE; CEREBRAL ISCHEMIA/REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; BRAIN-BARRIER INTEGRITY; ANIMATION-LIKE STATE; ISCHEMIC-STROKE; METHYLENETETRAHYDROFOLATE REDUCTASE; HOMOCYSTEINE METABOLISM; INFLAMMATORY RESPONSE; SIGNALING MOLECULE;

D O I：

10.1016/j.neuint.2016.11.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogen sulfide is believed to be a signalling molecule in the central nervous system. It is known to increase rapidly following an ischemic insult in experimental stroke. Is it protective or deleterious? This review surveys the relevant information available in the literature. It appears that there is no definitive answer to this question at present. Current evidence seems to suggest that the presence of H2S in the ischemic brain may either be deleterious or protective depending on its concentration, deleterious when high and protective when low. Therefore, it can be inferred that either an enhancement or a reduction of its concentration may be of potential use in future stroke therapy. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：78 / 87

页数：10

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