Synthesis of nanoporous calcium carbonate spheres using double hydrophilic block copolymer poly(acrylic acid-b-N-isopropylacrylamide)

被引:10
|
作者
Guragain, Sudhina [1 ]
Torad, Nagy L. [1 ,2 ]
Alghamdi, Yousef Gamaan [3 ]
Alshehri, Abdulmohsen Ali [3 ]
Kim, Jeonghun [4 ,5 ]
Bastakoti, Bishnu Prasad [1 ]
Yamauchi, Yusuke [1 ,2 ,4 ,5 ,6 ]
机构
[1] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton WPI MANA, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[2] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, Qingdao 266042, Peoples R China
[3] King Abdulaziz Univ, Dept Chem, POB 80203, Jeddah 21589, Saudi Arabia
[4] Univ Queensland, Sch Chem Engn, Brisbane, Qld 4072, Australia
[5] Univ Queensland, AIBN, Brisbane, Qld 4072, Australia
[6] Kyung Hee Univ, Dept Plant & Environm New Resources, 1732 Deogyeong Daero, Yongin 446701, Gyeonggi Do, South Korea
基金
澳大利亚研究理事会;
关键词
Nanoporous materials; Micelles; Calcium carbonate; Double hydrophilic block copolymer; Drug release; DRUG-DELIVERY; TEMPLATE; NANOPARTICLES; RELEASE;
D O I
10.1016/j.matlet.2018.07.060
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
We report self-assembly of double hydrophilic block copolymer poly(acrylic acid-b-N-isopropylacrylamide) in aqueous solution. Self-assembly of calcium ions chelated complex micelles upon mineralization reaction forms calcium carbonate (CaCO3) sphere. High porosity on CaCO3 spheres can accommodate a large amount of anticancer drug (doxorubicin) and achieve sustainable drug release. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:143 / 147
页数:5
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