Stereoselective Synthesis of C1-C7 and C6-C22 Fragments of Phostriecin, Goniothalamines, and Their Analogues

被引：5

作者：

Reddy, K. Purushotham ^{[1
]}

Reddy, D. Vasudeva ^{[1
]}

Sabitha, Gowravaram ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 32期

关键词：

Stereoselectivity; Synthesis design; Cross metathesis; Natural products; SHARPLESS KINETIC RESOLUTION; STYRYL-LACTONES; ASYMMETRIC EPOXIDATION; METATHESIS CATALYSTS; (+)-ASPERLIN; (+)-ACETYLPHOMALACTONE; MOIETY; RUCL2(=CHR)(PR(3))(2); (+)-STRICTIFOLIONE; ISOALTHOLACTONE;

D O I：

10.1002/ejoc.201800561

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The stereoselective synthesis of two fragments (C1-C7 and C6-C22) of the anti-tumor agent phostriecin has been achieved. The chiral hydroxy-vinyl--lactone building block (fragment C1-C7) was subsequently utilized for the synthesis of 5-hydroxygoniothalamin, 5-acetoxygoniothalamin, and their derivatives.

引用

页码：4389 / 4399

页数：11

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