Shedding of ligands for the activating immunoreceptor NKG2D from the surface of metastasizing tumor cells by platelet-derived proteases impairs NK cell immunosurveillance

被引：0
|
作者：
Raab, S. [1 ]
Kropp, K. N. [1 ]
Steinle, A. [2 ]
Klein, G. [1 ]
Kanz, L. [1 ]
Kopp, H. -G. [1 ]
Salih, H. R. [3 ,4 ,5 ]
机构：
[1] Univ Tubingen, Dept Hematol & Oncol, Tubingen, Germany
[2] Goethe Univ Frankfurt, Inst Mol Med, D-60054 Frankfurt, Germany
[3] Univ Tubingen, Dept Hematol & Oncol, Tubingen, Germany
[4] German Canc Consortium DKTK, Heidelberg, Germany
[5] German Canc Res Ctr, Heidelberg, Germany
来源：
ONCOLOGY RESEARCH AND TREATMENT | 2014年 / 37卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
V668
引用
收藏
页码：214 / 214
页数：1
相关论文
共 50 条
  • [1] Platelets Impair NK Cell Immunosurveillance Of Metastasizing Tumor Cells By Altering Surface Expression and Shedding Of Ligands For The Activating Immunoreceptor NKG2D
    Raab, Stefanie
    Kropp, Korbinian Nepomuk
    Steinle, Alexander
    Kanz, Lothar
    Kopp, Hans-Georg
    Salih, Helmut R.
    BLOOD, 2013, 122 (21)
  • [2] Platelets impair NK cell immunosurveillance by altering expression and shedding of ligands for the activating immunoreceptor NKG2D from the surface of metastasizing tumor cells
    Raab, S.
    Kropp, K. N.
    Steinle, A.
    Kanz, L.
    Kopp, H. -G
    Salih, H. R.
    ONKOLOGIE, 2013, 36 : 242 - 243
  • [3] Surface expression and shedding of NKG2D ligands by (metastasizing) tumor cells is altered by platelets leading to impaired NK cell immunosurveillance
    Raab, Stefanie
    Kropp, Korbinian Nepomuk
    Steinle, Alexander
    Klein, Gerd
    Kopp, Hans-Georg
    Salih, Helmut R.
    CANCER RESEARCH, 2014, 74 (19)
  • [4] Platelet-Derived Proteases ADAM10 and ADAM17 Impair NK Cell Immunosurveillance of Metastasizing Tumor Cells By Diminishing NKG2D Ligand Surface Expression
    Raab, Stefanie
    Kropp, Korbinian Nepomuk
    Steinle, Alexander
    Klein, Gerd
    Kanz, Lothar
    Kopp, Hans-Georg
    Salih, Helmut R.
    BLOOD, 2014, 124 (21)
  • [5] Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells
    Maurer, Stefanie
    Kropp, Korbinian Nepomuk
    Klein, Gerd
    Steinle, Alexander
    Haen, Sebastian P.
    Walz, Juliane S.
    Hinterleitner, Clemens
    Maerklin, Melanie
    Kopp, Hans-Georg
    Salih, Helmut Rainer
    ONCOIMMUNOLOGY, 2018, 7 (02):
  • [6] Comprehensive analysis of the involvement of the activating immunoreceptor NKG2D and its ligands in NK cell reactivity against leukemia
    Hilpert, J.
    Buechele, C.
    Gruenebach, F.
    Steinle, A.
    Kanz, L.
    Baessler, T.
    Salih, H. R.
    ONKOLOGIE, 2010, 33 : 220 - 220
  • [7] Tumor cell recognition by the NK cell activating receptor NKG2D
    Bryceson, Yenan T.
    Ljunggren, Hans-Gustaf
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (11) : 2957 - 2961
  • [8] "Acquired" NKG2D Ligand Stimulates NK Cell-mediated Tumor Immunosurveillance
    Wang, Dongfang
    Gu, Xiuling
    Liu, Xinjun
    Liu, Xiaoman
    Wang, Bin
    Lao, Fengxue
    Fang, Min
    JOURNAL OF IMMUNOTHERAPY, 2019, 42 (06) : 189 - 196
  • [9] Identification and characterisation of porcine ligands for the human NK cell activating receptor NKG2D
    Tran, P
    Christiansen, D
    Sandrin, M
    Sharland, A
    IMMUNOLOGY AND CELL BIOLOGY, 2005, 83 (04): : A24 - A24
  • [10] NK Cell Anti-Tumor Reactivity Is Impaired by Platelet-Derived TGF-B through NKG2D Downregulation.
    Kopp, Hans-Georg
    Placke, Theresa
    Schmiedel, Benjamin J.
    Kanz, Lothar
    Krusch, Matthias
    Salih, Helmut R.
    BLOOD, 2008, 112 (11) : 986 - 987
12345