Toward the development of α1a adrenergic receptor antagonists

被引：36
|
作者：
Bock, MG [1 ]
Patane, MA [1 ]
机构：
[1] Merck Res Labs, West Point, PA 19486 USA
来源：
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 35 | 2000年 / 35卷
关键词：
D O I：
10.1016/S0065-7743(00)35021-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：221 / 230
页数：10
相关论文
共 50 条
  • [1] Phenylacetamides as selective α-1A adrenergic receptor antagonists
    Patane, MA
    DiPardo, RM
    Newton, RC
    Price, RP
    Broten, TP
    Chang, RSL
    Ransom, RW
    Di Salvo, J
    Nagarathnam, D
    Forray, C
    Gluchowski, C
    Bock, MG
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) : 1621 - 1624
  • [2] Cyclic imides as potent and selective α-1A adrenergic receptor antagonists
    DiPardo, RM
    Patane, MA
    Newton, RC
    Price, RA
    Broten, TP
    Chang, RSL
    Ransom, RW
    Di Salvo, J
    Freidinger, RM
    Bock, MG
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (14) : 1959 - 1962
  • [3] Cyclic imides as potent and selective α-1a adrenergic receptor antagonists.
    DiPardo, RM
    Patane, MA
    Price, RP
    Newton, RC
    DiSalvo, J
    Broten, TP
    Chang, RSL
    Ransom, RW
    Freidlinger, RM
    Bock, MG
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2000, 220 : U589 - U589
  • [4] Pharmacophore development for antagonists at alpha(1) adrenergic receptor subtypes
    Bremner, JB
    Coban, B
    Griffith, R
    JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 1996, 10 (06) : 545 - 557
  • [5] Design and synthesis of N-alkylated saccharins as selective α-1A adrenergic receptor antagonists
    Nerenberg, JB
    Erb, JM
    Thompson, WJ
    Lee, HY
    Guare, JP
    Munson, PM
    Bergman, JM
    Huff, JR
    Broten, TP
    Chang, RSL
    Chen, TB
    O'Malley, S
    Schorn, TW
    Scott, AL
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (18) : 2467 - 2472
  • [6] Arylpiperazine substituted heterocycles as selective α1a adrenergic antagonists
    Khatuya, H
    Hutchings, RH
    Kuo, GH
    Pulito, VL
    Jolliffe, LK
    Li, XB
    Murray, WV
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (17) : 2443 - 2446
  • [7] Selective α-1A adrenergic receptor antagonists.: Effects of pharmacophore regio- and stereochemistry on potency and selectivity
    Patane, MA
    DiPardo, RM
    Price, RP
    Chang, RSL
    Ransom, RW
    O'Malley, SS
    Di Salvo, J
    Bock, MG
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (18) : 2495 - 2500
  • [8] Effects of α1-adrenergic receptor antagonists on the development and progression of urothelial cancer
    Nagata, Yujiro
    Kawahara, Takashi
    Goto, Takuro
    Inoue, Satoshi
    Teramoto, Yuki
    Jiang, Guiyang
    Fujimoto, Naohiro
    Miyamoto, Hiroshi
    AMERICAN JOURNAL OF CANCER RESEARCH, 2020, 10 (12): : 4386 - 4398
  • [9] Selective α1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones
    Nantermet, PG
    Barrow, JC
    Selnick, HG
    Homnick, CF
    Freidinger, RM
    Chang, RSL
    O'Malley, SS
    Reiss, DR
    Broten, TP
    Ransom, RW
    Pettibone, DJ
    Olah, T
    Forray, C
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (15) : 1625 - 1628
  • [10] New development in α-1 adrenergic receptors antagonists
    Malawska, B
    Kulig, K
    Proceedings of the Joint Meeting on Medicinal Chemistry, 2005, : 21 - 26
12345