SYNTHESIS OF SOME 4-METHYL-2-(3-METHYLBENZOFURAN-2-YL)QUINOLINE-3-CARBOXYLIC ACIDS

被引：0
|
作者：
Fu, Xin B. [1 ]
Li, Yang [1 ]
Gao, Wen T. [1 ]
机构：
[1] Bohai Univ, Inst Superfine Chem, Jinzhou, Liaoning, Peoples R China
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2016年 / 26卷 / 1-2期
基金：
中国国家自然科学基金;
关键词：
Quinoline; Benzofuran; 1-(2-Hydroxyphenyl)ethanone; One-pot; Synthesis; ANTIVIRAL ACTIVITY; FACILE SYNTHESIS; 1ST SYNTHESIS; DERIVATIVES; ANTIBACTERIAL; CYTOTOXICITY; CONSTRUCTION; INHIBITORS; DOCKING; ANALOGS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the present investigation, one-pot synthetic route for the synthesis of 4-methyl-2-(3-methylbenzofuran-2-yl))quinoline-3-carboxylic acids 3a-f has been described, involving the reaction of ethyl 2-(chloromethyl)-4-methylquinoline-3-carboxylate (1) with various 1-(2-hydroxyphenyl)ethanones 2a-f in refiuxing MeCN with the presence of K2CO3 as base and PEG-400 as phase transfer catalyst. The structures of all the newly-synthesized compounds were confirmed by IR, (HNMR)-H-1, (CNMR)-C-13 and HRMS.
引用
收藏
页码：87 / 93
页数：7
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