Fourier analysis of energy transfer data obtained by simulating a 14-MeV α-particle in water

Data from Monte Carlo transport codes are used to model radiobiological effects. We previously reported the Fourier analysis of ionization data generated by simulating a 500-keV proton traversing water. Here, we extend Fourier analysis to energy transfer data of another radiation type, a 14-MeV alpha-particle A. radiobiological model based on this frequency-domain analysis views cell as an information processing system [8]. It lends itself naturally to traditional engineering analyses. One engineering principle-the output response of a linear system to random signal-is applied here to explain the fact that there is measurable difference in the magnitude of the biological effectiveness when a given biological system is irradiated with two different radiation types of the same Linear Energy Transfer (LET). (C) 2009 Elsevier B.V. All rights reserved.