Direct active oxygen radical scavenging activity of indomethacin; Cyclooxygenase (COX) inhibitor and its inhibition of lipid peroxidation of mouse brain tissues

被引：0
|
作者：
Ikeda, Y [1 ]
Matsumoto, K [1 ]
Dohi, K [1 ]
Jimbo, H [1 ]
Hayashi, M [1 ]
Sasaki, K [1 ]
Satoh, K [1 ]
机构：
[1] Showa Univ, Sch Med, Dept Neurosurg, Tokyo 142, Japan
来源：
MANAGEMENT OF PAIN A WORLD PERSPECTIVE | 2000年
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Indomethacin; non-steroidal anti-inflammatory drug (NSAID) inactivates cyclooxygenase (COX). The present study was performed to investigate the effect of indomethacin on active oxygen species and the inhibitory effect of brain lipid peroxidation. Measurement of free radical scavenging activities of indomethacin was performed by electron spin resonance (ESR). The inhibitory effect of indomethacin on lipid peroxidation of the mouse brain tissues was measured by thiobarbituric acid test. Indomethacin can scavenge free radicals directly and have lipid peroxidation inhibitory abilities.
引用
收藏
页码：155 / 158
页数：4
相关论文
共 17 条
  • [1] INHIBITION OF LIPID PEROXIDATION AND RADICAL SCAVENGING ACTIVITY OF SYNTHESIZED CURCUMIN AND BISDEMETHOXYCURCUMIN IN FOOD SYSTEMS
    Vinh Tien Nguyen
    Hao Minh Hoang
    CARPATHIAN JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2021, 13 (02) : 74 - 83
  • [2] Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L.
    Tsuda, T
    Shiga, K
    Ohshima, K
    Kawakishi, S
    Osawa, T
    BIOCHEMICAL PHARMACOLOGY, 1996, 52 (07) : 1033 - 1039
  • [3] Antioxidant activity of Hizikia fusiformis on reactive oxygen species scavenging and lipid peroxidation inhibition
    Siriwardhana, N
    Lee, KW
    Kim, SH
    Ha, JW
    Jeon, YJ
    FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL, 2003, 9 (05) : 339 - 346
  • [4] Comparison of antioxidant activities of onion and garlic extracts by inhibition of lipid peroxidation and radical scavenging activity
    Nuutila, AM
    Puupponen-Pimiä, R
    Aarni, M
    Oksman-Caldentey, KM
    FOOD CHEMISTRY, 2003, 81 (04) : 485 - 493
  • [5] Lipophilic and hydrophilic antioxidants, lipid peroxidation inhibition and radical scavenging activity of two Lamiaceae food plants
    Fernandes, Angela S. F.
    Barros, Lillian
    Carvalho, Ana Maria
    Ferreira, Isabel C. F. R.
    EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, 2010, 112 (10) : 1115 - 1121
  • [6] QCAR models to predict wild mushrooms radical scavenging activity, reducing power and lipid peroxidation inhibition
    Froufe, Hugo J. C.
    Abreu, Rui M. V.
    Ferreira, Isabel C. F. R.
    CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS, 2011, 109 (02) : 192 - 196
  • [7] Lipid peroxidation inhibition, free radical scavenging activity and electrochemical behaviour of a dihydroxylated di(hetero)arylamine
    Ferreira, Isabel C. F. R.
    Barros, Lillian
    Falcao, S.
    Boas, Miguel Vilas
    Queiroz, Maria-Joao R. P.
    FREE RADICAL RESEARCH, 2007, 41 : S26 - S26
  • [8] Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: radical scavenging activity, lipid peroxidation inhibition and redox profile
    Calhelha, Ricardo C.
    Peixoto, Daniela
    Boas, Miguel Vilas
    Queiroz, Maria-Joao R. P.
    Ferreira, Isabel C. F. R.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2014, 29 (03) : 311 - 316
  • [9] Brain lipid peroxidation, radical scavenging effects and antitumor activity of taiwanese botany-YY-24 on human glioblastoma cells
    Yang, L. L.
    Yu, Y. W.
    Huang, W. T.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 : S443 - S444
  • [10] Brain lipid peroxidation, radical scavenging effects and antitumor activity of taiwanese botany-YY-07 on human glioblastoma cells
    Yu, Y. W.
    Huang, W. T.
    Yang, L. L.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 : S445 - S446
12