Development of biocompatible glue for minimum invasive therapy

被引：3
|
作者：
Taguchi, T. [1 ]
Saito, H. [2 ]
Iwasashi, M. [3 ]
Sakane, M. [3 ]
Kakinoki, S. [1 ]
Ochiai, N. [3 ]
Tateishi, T. [1 ]
机构：
[1] NIMS, Ctr Biomat, 1-1 Namiki, Tsukuba, Ibaraki 3050044, Japan
[2] Furuuchi Chem Corp, Tokyo 1400013, Japan
[3] Univ Tsukuba, Tsukuba, Ibaraki 3058575, Japan
来源：
BIOCERAMICS, VOL 19, PTS 1 AND 2 | 2007年 / 330-332卷
关键词：
human serum albumin; glue; citric acid; N-hyroxysuccinimide; crosslink;
D O I：
10.4028/www.scientific.net/KEM.330-332.1339
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A biocompatible glue consisting of human serum albumin (HSA) and citric acid derivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by the reaction between citric acid and N-hydroxysuccinimide in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagen-based casings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bonding strength of this glue to collagen-based casings increased with increasing of HSA concentration. The bonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, and then decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%). The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to the mouse skin. These results suggested that this developed glue had both tissue compatibility and bonding strength for use in clinical field.
引用
收藏
页码：1339 / +
页数：2
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