Development of edema in nervous tissue in the model of hemorrhagic stroke in vitro

The development of edema in the surviving olfactory cortex slices by the control of bioelectric activity of neurons under the long-term influence of autoblood has been studied. The level of disturbance of neuronal activity was revealed by comparing focal potentials with their control values; the degree of tissue swelling was detected by their weigting before and at various time-points after exposure to autoblood. The use of this model of hemorrhagic stroke and pharmacological blockade of glutamate receptors allowed to find the correlation between the degree of edema in nervous tissue and the level of activity of ionotropic and metabotropic glutamate receptors.