High-versus low-dose oxytocin for augmentation or induction of labor

Objective: To compare the use of high- and low-dose oxytocin for augmentation or induction of labor. Data Sources: Clinical trials were accessed through MEDLINE (1966-November 2003). Published literature relevant to the use of oxytocin for augmentation or induction of labor was evaluated. Study Selection and Data Extraction: Articles identified from the data sources were evaluated and included if they were clinical trials comparing high- versus low-dose oxytocin for augmentation or induction of labor. Data Synthesis: Oxytocin is a treatment of choice for augmentation and induction of labor; however, no consensus exists regarding optimal dosing. Relevant studies comparing high-dose (2-6 mU/min) and low-dose (1-2 mU/min) therapy for labor augmentation and induction were evaluated. Conclusions: High-dose oxytocin decreases the time from admission to vaginal delivery, but does not appear to decrease the incidence of cesarean sections when compared with low-dose therapy.