Cobalt-catalyzed asymmetric hydrogenation of ketones: A remarkable additive effect on enantioselectivity

被引：19
|
作者：
Du, Tian [1 ]
Wang, Biwen [1 ]
Wang, Chao [1 ]
Xiao, Jianliang [2 ]
Tang, Weijun [1 ]
机构：
[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Key Lab Appl Surface & Colloid Chem, Minist Educ, Xian 710062, Peoples R China
[2] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Cobalt; Asymmetric hydrogenation; Ketones; Additive effect; Pincer complex; SELECTIVE HYDROGENATION; AMINO-ALCOHOLS; COMPLEXES; IRON; DEHYDROGENATION; MILD; C=O; LIGANDS; ACID;
D O I：
10.1016/j.cclet.2020.09.011
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A chiral cobalt pincer complex, when combined with an achiral electron-rich mono-phosphine ligand, catalyzes efficient asymmetric hydrogenation of a wide range of aryl ketones, affording chiral alcohols with high yields and moderate to excellent enantioselectivities (29 examples, up to 93% ee). Notably, the achiral mono-phosphine ligand shows a remarkable effect on the enantioselectivity of the reaction. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1241 / 1244
页数：4
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