Heterogeneity and penetration of HIV-1 non-subtype B viruses in an Italian province: public health implications

被引:9
|
作者
Torti, C. [1 ]
Lapadula, G. [2 ]
Izzo, I.
Brindicci, G. [3 ]
Labbate, G. [4 ]
Quiros-Roldan, E.
Diallo, I.
Gargiulo, F. [4 ]
Castelnuovo, F. [5 ]
Calabresi, A.
Carosi, G.
Manca, N. [4 ]
Monno, L. [3 ]
机构
[1] Univ Brescia, Sch Med, Inst Infect & Trop Dis, I-25123 Brescia, Italy
[2] S Gerardo Hosp, Clin Infect Dis, Monza, Italy
[3] Univ Bari, Inst Infect Dis, Bari, Italy
[4] Univ Brescia, Inst Microbiol, Brescia, Italy
[5] Spedali Civil Brescia, Dept Infect Dis, I-25125 Brescia, Italy
来源
EPIDEMIOLOGY AND INFECTION | 2010年 / 138卷 / 09期
关键词
HIV subtypes; MOLECULAR EPIDEMIOLOGY; TYPE-1; PREVALENCE; INFECTION; STRAINS; FRANCE; ORIGIN;
D O I
10.1017/S0950268810000166
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
This study assessed changes in prevalence and distribution of HIV-1 non-subtype B viruses in Italian and immigrant patients over two decades in a province in Italy. All HIV-positive patients who underwent genotypic resistance testing were selected. Prevalence of non-subtype B viruses in 3-year periods was calculated. All sequences of non-subtype B and those provided by REGA as unassigned were analysed for phylogenetic relationships. In total, 250/1563 (16%) individuals were infected with a non-subtype B virus. Prevalence increased over time, reaching a peak (31.5%) in 2004-2006. In Italian patients, the most frequent subtypes were B (92.5%) and F1 (4%). F1 subtype was also prevalent in patients from South America (13.6%); in patients of African origin, CRF02_AG (54.9%) and G (12.3%) were the most frequent. HIV-1 non-subtype B infections in Italians were mostly found in patients who acquired HIV sexually. A phylogenetic relationship between F subtypes in Italian and representative HIV-1 sequences from Brazil was found. C subtypes in Italians were phylogenetically related to subtypes circulating in Brazil. Inter-subtype recombinants were also found in the latest years. The HIV-1 epidemic in Brescia province evolved to the point where about 1/3 patients recently diagnosed harboured non-B HIV subtypes. The distribution of HIV-1 non-B subtypes in Italian patients resembled that in South American patients and phylogenetic relatedness between some Italian and South American HIV-1 strains was found. The possible epidemiological link between these two populations would have been missed by looking only at risk factors for HIV acquisition declared by patients. The evidence of inter-subtype recombinants points to significant genetic assortment. Overall our results support phylogenetic analysis as a tool for epidemiological investigation in order to guide targeted prevention strategies.
引用
收藏
页码:1298 / 1307
页数:10
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