A Novel Ca(II) Complex for Inhibiting Growth of Human Nasopharyngeal Carcinoma Cells

By using the flexible carboxylic organic ligand H3TATB and 1D chain-like secondary building unit, a new Ca(II)-coordination polymer, namely {[Ca-3(TATB)(2)(H2O)(2)](DMA)(4)}(n) (1, H(3)TATB = 4,4', 4 ''-s-triazine-1,3,5-triyltri-p-aminobenzoate, DMA = N, N-dimethylacetamide) has been synthesized under solvothermal conditions. Single crystal X-ray structural analysis reveals that compound 1 features a non-interpenetrating 3D networks with 1D rhombic channels running along the a axis. The antitumor activity of compound 1 and its corresponding organic ligand H(3)TATB were then investigated against three human nasopharyngeal carcinoma cell lines (CNE1, HONE1 and C666-1) by MTT assay. It was found that compared with H(3)TATB, compound 1 exerted rather potent activities against all of these cell lines.