Base-Free Dynamic Kinetic Resolution of Secondary Alcohols with a Ruthenium-Lipase Couple

被引：13

作者：

Yun, Inyeol ^{[1
]}

Park, Jin Yong ^{[1
]}

Park, Jaiwook ^{[1
]}

Kim, Mahn-Joo ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, 77 Cheongam Ro, Pohang 37673, South Korea

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

ALLYLIC ALCOHOLS; CATALYTIC RACEMIZATION; ENZYMATIC RESOLUTION; COMPLEXES; METAL;

D O I：

10.1021/acs.joc.9b02510

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the dynamic kinetic resolution (DKR) of various secondary alcohols by the combination of a ruthenium catalyst and an anionic surfactant-activated lipoprotein lipase. The DKR reactions performed under totally base-free conditions at room temperature provided the products of excellent enantiopurities (91-99% ee or greater) in high yields (92-99%). More importantly, the DKR of alpha-arylallyl alcohols was achieved for the first time with high yields (87-91%).

引用

页码：16293 / 16298

页数：6

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