Gonadotropin-releasing hormone agonist inhibits estrone sulfatase expression of cystic endometriosis in the ovary

被引:10
|
作者
Maitoko, K [1 ]
Sasaki, H [1 ]
机构
[1] Jikei Univ, Sch Med, Dept Obstet & Gynecol, Minato Ku, Tokyo 1058461, Japan
关键词
estrone sulfatase; GnRH agonist; cystic endometriosis; ovary;
D O I
10.1016/j.fertnstert.2003.12.044
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To clarify the inhibitory effect of GnRH agonist on estrone (E-1) sulfatase expression. Design: Retrospective immunohistochemical study. Setting: The Jikei University Hospital, Tokyo, Japan. Patient(s): Thirty-three women who had undergone cystectomy of the ovary or oophorectomy and were proved histopathologically to have cystic endometriosis in the ovary. Intervention(s): Fifteen of the 33 patients were treated with GnRH agonists monthly for 2-6 months before surgery. The other 18 patients did not receive any hormonal therapy. Tissue sections were immunostained with an anti-E-1 sulfatase monoclonal antibody (KM1049) originating from human placenta. Main Outcome Measure(s): Microscopic evaluation to assess the presence and localization of E-1 sulfatase and to describe any variations in its expression with or without treatment with GnRH agonist. Result(s): Immunostaining showed that E-1 sulfatase was localized only on the glandular epithelial cells of cystic endometriosis in the ovary. The immunostaining with anti-E-1 sulfatase proved that GnRH agonist inhibited E-1 sulfatase expression in the cystic endometriosis in the ovary. Conclusion(s): Gonadotropin-releasing hormone agonist inhibits E-1 sulfatase expression in cystic endometriosis in the ovary.
引用
收藏
页码:322 / 326
页数:5
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