Antioxidant and Ex Vivo Immune System Regulatory Properties of Boswellia serrata Extracts

被引:36
|
作者
Beghelli, Daniela [1 ]
Isani, Gloria [2 ]
Roncada, Paola [2 ]
Andreani, Giulia [2 ]
Bistoni, Onelia [3 ]
Bertocchi, Martina [2 ]
Lupidi, Giulio [4 ]
Alunno, Alessia [3 ]
机构
[1] Univ Camerino, Sch Biosci & Vet Med, Camerino, Italy
[2] Univ Bologna, Dept Vet Med Sci, Ozzano Dell Emilia, Italy
[3] Univ Perugia, Dept Clin & Expt Med, Rheumatol Unit, Perugia, Italy
[4] Univ Camerino, Sch Pharm & Hlth Prod Sci, Camerino, Italy
关键词
IN-VITRO; OXIDATIVE STRESS; CELLS; RESIN; ACIDS; INFLAMMATION; INHIBITION; COMPOUND; CARTERII; ALPHA;
D O I
10.1155/2017/7468064
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Boswellia serrata (BS) is an important traditional medicinal plant that currently represents an interesting topic for pharmaceutical research since it possesses several pharmacological properties (e.g., anti-inflammatory, antimicrobial, and antitumour). The safety and versatility of this dietary supplement should allow for its use in numerous pathological conditions; however the quality of the extracts needs to be standardized to increase the clinical success rate resulting from its use. In the present study, different commercially available B. serrata extracts were employed to compare their AKBA content and in vitro antioxidant power. Furthermore, their ability to modulate the immune system regulatory properties was investigated. Our results showed that the AKBA content varied from 3.83 +/- 0.10 to 0.03 +/- 0.004%, with one sample in which it was not detectable. The highest antioxidant power and phenolic content were shown by the same extract, which also exhibited the highest AKBA concentration. Finally, the BS extracts showed the ability to influence the regulatory and effector T-cell compartments. Our results suggest that frankincense should be further investigated for its promising potentiality to modulate not only inflammation/oxidative stress but also immune dysregulation, but attention should be paid to the composition of the commercial extracts.
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页数:10
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