Production of L-DOPA under heterogeneous asymmetric catalysis

被引：35

作者：

Valdés, RH

Puzer, L

Gomes, M

Marques, CESJ

Aranda, DAG

Bastos, ML

Gemal, AL

Antunes, OAC

机构：

[1] UFRJ, Inst Quim, Lab 641, BR-21945970 Rio De Janeiro, Brazil

[2] UFRJ, Escola Quim, BR-21945970 Rio De Janeiro, Brazil

[3] Univ Estacio Sa, BR-20261063 Rio De Janeiro, Brazil

来源：

CATALYSIS COMMUNICATIONS | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1016/j.catcom.2004.07.018

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

To generalize the use of heterogeneous asymmetric catalysis we developed a new process to produce L-DOPA via cinchonine mediated Pd/C asymmetric reduction of the corresponding cinnamic acid precursor. Reaction proceeded well giving rise to good optical yield (44%). The use of O, O'-dibenzyl groups in the substrate appears to be the key to this optical purity and deserves further investigation. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：631 / 634

页数：4

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