Biocatalytic production of chiral pharmaceutical intermediates

被引：30
|
作者：
Mahmoudian, M [1 ]
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
来源：
BIOCATALYSIS AND BIOTRANSFORMATION | 2000年 / 18卷 / 02期
关键词：
nucleoside oxidase; savinase (TM); uridine phosphorylase; purine nucleoside phosphorylase; ziagen (TM) (abacavir); 506U78; regioselective acylation; anti-inflammatory; anti-viral and anti-leukaemic agents; fermentation scale up;
D O I：
10.3109/10242420009015240
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biocatalytic production of several key chiral intermediates in the synthesis of anti-inflammatory, anti-viral and anti-leukaemic agents is described. These include (i) a nucleoside oxidase from Stenotrophomonas maltophilia to oxidise unnatural purine nucleosides, (ii) a serine-type protease from an alkalophilic Bacillus sp. to resolve racemic N-substituted lactams, and (iii) a co-immobilised uridine phosphorylase and purine nucleoside phosphorylase preparation from recombinant E. coli strains that catalyse base transfer reactions.
引用
收藏
页码：105 / 118
页数：14
相关论文
共 50 条
12345