Porcine Pancreatic Lipase as a Catalyst in Organic Synthesis

The article is a mini-review of the porcine pancreatic lipase (PPL) application as a catalyst in organic synthesis. Together with well-known stereo-selective hydrolysis and synthesis there were described examples of new (opened mostly last decade) PPL-catalyzed reactions: Michael and thio-Michael addition, aldol condensation, Henry reaction, Morita-Baylis-Hillman reaction, Knoevenagel condensation, Mannich reaction, one-pot catalysis of some multicomponent reactions, polymerization of different monomers. The study of potential new catalytic capabilities of PPL in organic synthesis permits successfully expand the range of biotechnological applications of this enzyme at both laboratory and industrial levels.