Catechol based inhibitors of 15-lipoxygenase

被引：5
|
作者：
Tait, BD
Dyer, RD
Auerbach, BJ
Bornemeier, D
GuildsZamarka, L
Oxender, M
Roth, BD
Trivedi, BK
Cornicelli, JA
机构：
[1] PARKE DAVIS PHARMACEUT RES,DEPT ATHEROSCLEROSIS THERAPEUT,ANN ARBOR,MI 48105
[2] PARKE DAVIS PHARMACEUT RES,DEPT BIOCHEM,ANN ARBOR,MI 48105
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 01期
关键词：
D O I：
10.1016/0960-894X(95)00565-B
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15-lipoxygenase.
引用
收藏
页码：93 / 96
页数：4
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