Pharmacology of moxonidine:: An I1-imidazoline receptor agonist

被引：36
|
作者：
Ernsberger, P [1 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Div Hypertens, Dept Nutr, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Med Hypertens, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Dept Pharmacol & Neurosci, Cleveland, OH 44106 USA
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 2000年 / 35卷
关键词：
imidazoline receptor; moxonidine; radioligand binding; PC12 pheochromocytoma cells; rats;
D O I：
10.1097/00005344-200000004-00005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The I-1-imidazoline receptor is a novel neurotransmitter receptor found mainly in the brainstem, adrenal medulla and kidney. The actions of moxonidine are described at the level of individual biomolecules, cells, tissues, organs and finally with integrative functions. The receptor functions at the cellular level works through arachidonic acid and phospholipid signaling cascades in neuronal cells with the net result of inhibiting sympathetic premotor neurons.
引用
收藏
页码：S27 / S41
页数：15
相关论文
共 50 条
  • [1] Pharmacology of moxonidine, an I-1-imidazoline receptor agonist
    Ziegler, D
    Haxhiu, MA
    Kaan, EC
    Papp, JG
    Ernsberger, P
    JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 27 : S26 - S37
  • [2] The I1-imidazoline receptor agonist moxonidine:: Molecular, cellular and organismic actions
    Ernsberger, P
    REVIEWS IN CONTEMPORARY PHARMACOTHERAPY, 1998, 9 (07): : 441 - 462
  • [3] The I1-imidazoline agonist moxonidine decreases sympathetic tone under physical and mental stress
    Wenzel, RR
    Mitchell, A
    Siffert, W
    Bührmann, S
    Philipp, T
    Schäfers, RF
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2004, 57 (05) : 545 - 551
  • [4] I1-imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in hypertensives
    Wenzel, RR
    Spieker, L
    Qui, S
    Shaw, S
    Lüscher, TF
    Noll, G
    HYPERTENSION, 1998, 32 (06) : 1022 - 1027
  • [5] I1-imidazoline receptor agonist -: moxonidine inhibits hyperventilation-induced changes in lung mechanics in guinea pig.
    Jakupaj, M
    Neziri, B
    Haxhui, MA
    Dreshaj, IA
    FASEB JOURNAL, 2001, 15 (05): : A862 - A862
  • [6] The I1-imidazoline agonist moxonidine decreases sympathetic nerve activity and blood pressure in human hypertension
    Wenzel, RR
    Spieker, L
    Qui, S
    Shaw, S
    JOURNAL OF HYPERTENSION, 1998, 16 : S236 - S236
  • [7] MOXONIDINE, A CENTRALLY ACTING ANTIHYPERTENSIVE AGENT, IS A SELECTIVE LIGAND FOR I1-IMIDAZOLINE SITES
    ERNSBERGER, P
    DAMON, TH
    GRAFF, LM
    SCHAFER, SG
    CHRISTEN, MO
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1993, 264 (01): : 172 - 182
  • [8] Cross-talk between I1-imidazoline and insulin receptor signaling:: A mechanism for moxonidine's antidiabetic actions?
    Edwards, L
    Ernsberger, P
    JOURNAL OF HYPERTENSION, 2000, 18 : S129 - S129
  • [9] INDIVIDUAL ANTIHYPERTENSIVE THERAPY WITH THE IMIDAZOLINE RECEPTOR AGONIST MOXONIDINE
    SCHREY, A
    HERZ KREISLAUF, 1995, 27 (11): : R3 - R4
  • [10] Contribution of I1-imidazoline and α2-adrenergic receptors to antihypertensive action of systemic moxonidine
    Khokhlova, ON
    Murashev, AN
    Medvedev, OS
    JOURNAL OF HYPERTENSION, 2000, 18 : S151 - S151
12345