High transplant-related mortality associated with haematopoietic stem cell transplantation for paediatric therapy-related acute myeloid leukaemia (t-AML). A study on behalf of the United Kingdom Paediatric Blood and Bone Marrow Transplant Group

被引：7

作者：

Gassas, Adam ^{[1
]}

Sivaprakasam, Ponni ^{[1
]}

Cummins, Michelle ^{[1
]}

Breslin, Patricia ^{[1
]}

Patrick, Katharine ^{[2
]}

Slatter, Mary ^{[3
]}

Skinner, Roderick ^{[3
]}

Shenton, Geof ^{[3
]}

Gibson, Brenda ^{[4
]}

Lawson, Sarah ^{[5
]}

Petterson, Toni ^{[6
]}

Potter, Michael ^{[6
]}

James, Beki ^{[7
]}

Hough, Rachael ^{[8
]}

Hiwarkar, Prashant ^{[9
]}

Vora, Ajay ^{[10
]}

Veys, Paul ^{[10
]}

De la Fuente, Josu ^{[11
]}

Wynn, Robert ^{[9
]}

Amrolia, Persis ^{[10
]}

机构：

[1] Royal Hosp Children, Dept Haematol & Oncol, Bristol, Avon, England

[2] Sheffield Childrens Hosp, Dept Haematol & Oncol, Sheffield, S Yorkshire, England

[3] Great North Childrens Hosp, Childrens Haemopoiet Stem Cell Transplant Unit, Newcastle Upon Tyne, Tyne & Wear, England

[4] Royal Hosp Children, Dept Haematol & Oncol, Glasgow, Lanark, Scotland

[5] Birmingham Childrens Hosp, Dept Haematol & Oncol, Birmingham, W Midlands, England

[6] Royal Marsden Hosp, Dept Haematol & Oncol, Sutton, Surrey, England

[7] Leeds Teaching Hosp, Dept Haematol & Oncol, Leeds, W Yorkshire, England

[8] UCL, Dept Haematol & Oncol, London, England

[9] Royal Manchester Childrens Hosp, Dept Haematol & Oncol, Manchester, Lancs, England

[10] Great Ormond St Hosp Sick Children, Dept Haematol & Oncol, London, England

[11] Imperial Coll, St Marys Hosp, Dept Haematol & Oncol, London, England

来源：

BONE MARROW TRANSPLANTATION | 2018年 / 53卷 / 09期

关键词：

MYELODYSPLASTIC SYNDROME; SECONDARY; CHILDREN; FLUDARABINE; BUSULFAN; AML;

D O I：

10.1038/s41409-018-0157-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Paediatric therapy-related acute myeloid leukaemia (t-AML) is rare and the outcome is poor. While allogeneic haematopoietic stem cell transplantation (HSCT) is generally the accepted modality of treatment, data regarding salvage chemotherapy, remission induction, conditioning regimens, transplant-related mortality and outcome is scarce. Between 2000 and2016, 36 children with t-AML were treated in seven UK paediatric HSCT centres. The most common salvage protocol for remission induction was FLAG with or without idarubicin and 28 patients were in complete morphological remission prior to BMT. Only 12 patients survived (33%). Transplant-related mortality (TRM) was the leading cause of death.

引用

页码：1165 / 1169

页数：5

共 27 条

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Adam Gassas
Ponni Sivaprakasam
Michelle Cummins
Patricia Breslin
Katharine Patrick
Mary Slatter
Roderick Skinner
Geof Shenton
Brenda Gibson
Sarah Lawson
Toni Petterson
Michael Potter
Beki James
Rachael Hough
Prashant Hiwarkar
Ajay Vora
Paul Veys
Josu De La Fuente
Robert Wynn
Persis Amrolia
Bone Marrow Transplantation, 2018, 53 : 1165 - 1169
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