Conservative management of cervical intraepithelial neoplasia (CIN2-3) in pregnant women

The management of cervical intraepithelial neoplasia (CIN2-3) diagnosed during pregnancy was the subject of this study. Two hundred and eight pregnant women with an abnormal cytology were assessed in our unit over a 10-year period. The age of the patients ranged from 20 to 45 (mean 28) years. Seventy-eight of these women were histologically proven to have CIN2-3. All patients were followed up every 8-10 weeks by cytology and colposcopy during pregnancy and reassessed 8-12 weeks postpartum. The disease persisted in 30 cases (38.4%), whereas in the remaining 48 cases it regressed to CIN1. No case of invasive disease developed during the follow-up period in these pregnant patients. Conservative management of CIN2-3 during pregnancy is acceptable, but close follow-up and colposcopic expertise are necessary. Copyright (C) 2003 S. Karger AG, Basel.