Site-specific metastases of intrahepatic cholangiocarcinoma and its impact on survival: a population-based study

被引：15
|
作者：
Yan, Xia [1 ,2 ]
Wang, Peng [1 ,2 ]
Zhu, Zhengfeng [1 ,2 ]
Ning, Zhouyu [1 ,2 ]
Xu, Litao [1 ,2 ]
Zhuang, Liping [1 ,2 ]
Sheng, Jie [1 ,2 ]
Meng, Zhiqiang [1 ,2 ]
机构：
[1] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Canc Ctr, Dept Integrat Oncol, Shanghai, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 18期
基金：
中国国家自然科学基金;
关键词：
intrahepatic cholangiocarcinoma; metastasis; prognosis; SEER; surgery; LONG-TERM SURVIVAL; UNITED-STATES; RISK-FACTORS; CANCER; RESECTION; CARCINOMA; THERAPY; SURGERY; CHEMOTHERAPY; STATISTICS;
D O I：
10.2217/fon-2018-0846
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Limited data exist on impact of the metastatic sites on survival in patients with metastatic intrahepatic cholangiocarcinoma (ICC). Methods: Patients with metastatic ICC were identified in the SEER from 2010 to 2015. Results: A total of 981 patients were identified, of this population, liver (57.9%) is the most common site of ICC metastases, followed by lung, bone and brain. Respective median overall survival and cancer-specific survival were 6 and 9months in entire population. Further analysis suggested that patients treated by surgery to primary and/or metastatic lesions had a better survival outcome than patients had no surgery (p <= 0.001). Conclusion: Liver is the most common site for ICC metastases, local treatment such as surgery to primary or metastatic lesions obviously benefit patients.
引用
收藏
页码：2125 / 2137
页数：13
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