Exploiting Copper Redox for 19F Magnetic Resonance-Based Detection of Cellular Hypoxia

被引：78
|
作者：
Xie, Da [1 ]
King, Tyler L. [1 ]
Banerjee, Arnab [1 ]
Kohli, Vikraant [1 ]
Que, Emily L. [1 ]
机构：
[1] Univ Texas Austin, Dept Chem, 105 E 24th St Stop A5300, Austin, TX 78712 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2016年 / 138卷 / 09期
关键词：
MRI CONTRAST AGENT; IMAGING TUMOR HYPOXIA; IN-VIVO; BIS(THIOSEMICARBAZONATO) COMPLEXES; PROTEASE ACTIVITY; PROBE; SELECTIVITY; MECHANISM; CELLS; RADIOPHARMACEUTICALS;
D O I：
10.1021/jacs.5b13215
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a pair of fluorinated, redox-active copper complexes for potential use as F-19 MRI contrast agents for detecting cellular hypoxia. Trifluorinated Cu(II) ATSM-F-3 displays the appropriate redox potential for selective accumulation in hypoxic cells and a completely quenched F-19 NMR signal that is "turned on" following reduction to Cu(I). Incubation of cancer cells with CuATSM-F-3 resulted in a selective detection of F-19 signal in cells grown under hypoxic conditions.
引用
收藏
页码：2937 / 2940
页数：4
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