Synthesis of β- and γ-Carbolinones via Pd-Catalyzed Direct Dehydrogenative Annulation (DDA) of Indole-carboxamides with Alkynes Using Air as the Oxidant

被引：131
|
作者：
Shi, Zhuangzhi [1 ]
Cui, Yuxin [1 ]
Jiao, Ning [1 ,2 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
[2] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 13期
基金：
美国国家科学基金会;
关键词：
C-H ACTIVATION; BOND FUNCTIONALIZATION; INTERNAL ALKYNES; OXIDATIVE CYCLIZATION; AROMATIC SUBSTITUTION; DERIVATIVES; PALLADIUM(II); ARYLATION; MULTIPLE; ANILINES;
D O I：
10.1021/ol1007839
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed direct dehydrogenative annulation (DDA) of indolecarboxamides with internal alkynes via C-H and N-H bond cleavage using air as the oxidant was developed. With this method, both beta- and gamma-carbolinones can be easily prepared under the mild conditions.
引用
收藏
页码：2908 / 2911
页数：4
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