Mendelian randomisation study of smoking exposure in relation to breast cancer risk

被引：14

作者：

Park, Hanla A. ^{[1
,2
]}

Neumeyer, Sonja ^{[1
]}

Michailidou, Kyriaki ^{[3
,4
,5
]}

Bolla, Manjeet K. ^{[5
]}

Wang, Qin ^{[5
]}

Dennis, Joe ^{[5
]}

Ahearn, Thomas U. ^{[6
]}

Andrulis, Irene L. ^{[7
,8
]}

Anton-Culver, Hoda ^{[9
]}

Antonenkova, Natalia N. ^{[10
]}

Arndt, Volker ^{[11
]}

Aronson, Kristan J. ^{[12
]}

Augustinsson, Annelie ^{[13
]}

Baten, Adinda ^{[14
]}

Freeman, Laura E. Beane ^{[6
]}

Becher, Heiko ^{[15
,16
]}

Beckmann, Matthias W. ^{[17
]}

Behrens, Sabine ^{[1
]}

Benitez, Javier ^{[18
,19
]}

Bermisheva, Marina ^{[20
]}

Bogdanova, Natalia, V ^{[10
,21
,22
]}

Bojesen, Stig E. ^{[23
,24
,25
]}

Brauch, Hiltrud ^{[26
,27
,28
]}

Brenner, Hermann ^{[11
,29
,30
,31
]}

Brucker, Sara Y. ^{[32
]}

Burwinkel, Barbara ^{[33
,34
]}

Campa, Daniele ^{[1
,35
]}

Canzian, Federico ^{[36
]}

Castelao, Jose E. ^{[37
]}

Chanock, Stephen J. ^{[6
]}

Chenevix-Trench, Georgia ^{[38
]}

Clarke, Christine L. ^{[39
]}

Conroy, Don M. ^{[40
]}

Couch, Fergus J. ^{[41
]}

Cox, Angela ^{[42
]}

Cross, Simon S. ^{[42
,43
]}

Czene, Kamila ^{[44
]}

Daly, Mary B. ^{[45
]}

Devilee, Peter ^{[46
,47
]}

Dork, Thilo ^{[22
]}

Dos-Santos-Silva, Isabel ^{[48
]}

Dwek, Miriam ^{[49
]}

Eccles, Diana M. ^{[50
]}

Eliassen, A. Heather ^{[51
,52
,53
]}

Engel, Christoph ^{[54
]}

Eriksson, Mikael ^{[44
]}

Evans, D. Gareth ^{[55
,56
]}

Fasching, Peter A. ^{[17
,57
]}

Flyger, Henrik ^{[58
]}

Fritschi, Lin ^{[59
]}

机构：

[1] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[2] Heidelberg Univ, Fac Med, Heidelberg, Germany

[3] Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus

[4] Cyprus Inst Neurol & Genet, Cyprus Sch Mol Med, Nicosia, Cyprus

[5] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

[6] NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA

[7] Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada

[8] Univ Toronto, Dept Mol Genet, Toronto, ON, Canada

[9] Univ Calif Irvine, Genet Epidemiol Res Inst, Dept Epidemiol, Irvine, CA USA

[10] NN Alexandrov Res Inst Oncol & Med Radiol, Minsk, BELARUS

[11] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany

[12] Queens Univ, Canc Res Inst, Dept Publ Hlth Sci, Kingston, ON, Canada

[13] Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden

[14] Univ Hosp Leuven, Leuven Multidisciplinary Breast Ctr, Leuven Canc Inst, Dept Oncol, Leuven, Belgium

[15] Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany

[16] Charite Univ Med Berlin, Inst Biometry & Clin Epidemiol, Berlin, Germany

[17] Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany

[18] Ctr Invest Red Enfermedades Raras CIBERER, Madrid, Spain

[19] Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain

[20] Russian Acad Sci, Inst Biochem & Genet, Ufa Fed Res Ctr, Ufa, Russia

[21] Hannover Med Sch, Dept Radiat Oncol, Hannover, Germany

[22] Hannover Med Sch, Gynaecol Res Unit, Hannover, Germany

[23] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Copenhagen Gen Populat Study, Herlev, Denmark

[24] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark

[25] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark

[26] Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany

[27] Univ Tubingen, iFIT Cluster Excellence, Tubingen, Germany

[28] German Canc Res Ctr, German Canc Consortium DKTK, Partner Site Tubingen, Tubingen, Germany

[29] German Canc Res Ctr, Div Prevent Oncol, Heidelberg, Germany

[30] Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[31] German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany

[32] Univ Tubingen, Dept Gynecol & Obstet, Tubingen, Germany

[33] German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany

[34] Heidelberg Univ, Univ Womens Clin Heidelberg, Mol Biol Breast Canc, Heidelberg, Germany

[35] Univ Pisa, Dept Biol, Pisa, Italy

[36] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

[37] Xerencia Xest Integrada Vigo SERGAS, Oncol & Genet Unit, Inst Invest Sanitaria Galicia Sur IISGS, Vigo, Spain

[38] QIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia

[39] Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia

[40] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England

[41] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[42] Univ Sheffield, Sheffield Inst Nucl Acids SInFoNiA, Dept Oncol & Metab, Sheffield, S Yorkshire, England

[43] Univ Sheffield, Acad Unit Pathol, Dept Neurosci, Sheffield, S Yorkshire, England

[44] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[45] Fox Chase Canc Ctr, Dept Clin Genet, 7701 Burholme Ave, Philadelphia, PA 19111 USA

[46] Leiden Univ Med Ctr, Dept Pathol, Leiden, Netherlands

[47] Leiden Univ Med Ctr, Dept Human Genet, Leiden, Netherlands

[48] London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London, England

[49] Univ Westminster, Sch Life Sci, London, England

[50] Univ Southampton, Fac Med, Southampton, Hants, England

来源：

BRITISH JOURNAL OF CANCER | 2021年 / 125卷 / 08期

基金：

英国医学研究理事会; 加拿大健康研究院; 美国国家卫生研究院; 瑞典研究理事会; 芬兰科学院; 英国惠康基金; 俄罗斯基础研究基金会;

关键词：

CIGARETTE-SMOKING; WOMEN; ALCOHOL; ASSOCIATION; INFERENCE; TOBACCO; TISSUE;

D O I：

10.1038/s41416-021-01432-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Results Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 x 10(-2)), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.

引用

页码：1135 / 1145

页数：11

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