Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19

被引：28

作者：

Abraham, George R. ^{[1
,2
]}

Kuc, Rhoda E. ^{[2
]}

Althage, Magnus ^{[3
]}

Greasley, Peter J. ^{[3
]}

Ambery, Philip ^{[3
]}

Maguire, Janet J. ^{[2
]}

Wilkinson, Ian B. ^{[2
]}

Hoole, Stephen P. ^{[1
]}

Cheriyan, Joseph ^{[2
,4
,5
]}

Davenport, Anthony P. ^{[2
]}

机构：

[1] Royal Papworth Hosp NHS Fdn Trust, Papworth Rd,Cambridge Biomed Campus, Cambridge CB2 0AY, England

[2] Univ Cambridge, Addenbrookes Hosp, Div Expt Med & Immunotherapeut, Cambridge, England

[3] AstraZeneca, BioPharmaceut R&D, Renal & Metab CVRM, Late Stage Dev,Cardiovasc, Gothenburg, Sweden

[4] Cambridge Univ Hosp NHS Fdn Trust, Clin Pharmacol Dept, Cambridge, England

[5] Cambridge Univ Hosp NHS Fdn Trust, Cardiovasc Off, Cambridge Clin Trials Unit, Cambridge, England

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2022年 / 167卷

基金：

英国惠康基金;

关键词：

Endothelin-1; Covid-19; Endotheliitis; Endothelin receptor antagonists;

D O I：

10.1016/j.yjmcc.2022.03.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target.ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection.The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.

引用

页码：92 / 96

页数：5

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