Cu-Catalyzed switchable synthesis of functionalized pyridines and pyrroles

被引：25

作者：

Ling, Zheng ^{[1
]}

Xie, Fang ^{[1
]}

Gridnev, Ilya D. ^{[2
]}

Terada, Masahiro ^{[2
]}

Zhang, Wanbin ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn & Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba Ku, Aramaki 3-6, Sendai, Miyagi 9808578, Japan

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 68期

基金：

中国国家自然科学基金;

关键词：

HIGHLY SUBSTITUTED PYRIDINES; DIAZO OXIME ETHERS; MULTICOMPONENT REACTIONS; AMINO-ALCOHOLS; DIELS-ALDER; CYCLOADDITION; REARRANGEMENT; HETEROCYCLES; ACCESS; IMINES;

D O I：

10.1039/c8cc05307c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we describe a high yielding and switchable synthesis of a range of functionalized pyridines and pyrroles via Cu-catalyzed cascade reactions with alkynes and N-sulfonyl azadienes which are readily available from saccharin. Both unsymmetrical 2,4,6-trisubstituted pyridines and multi-substituted pyrroles could be transformed into some bioactive compounds and chiral ligands.

引用

页码：9446 / 9449

页数：4

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