Virus-Induced Changes of the Respiratory Tract Environment Promote Secondary Infections With Streptococcus pneumoniae

被引：49
|
作者：
Sender, Vicky [1 ]
Hentrich, Karina [1 ]
Henriques-Normark, Birgitta [1 ,2 ]
机构：
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
[2] Karolinska Univ Hosp, Clin Microbiol, Solna, Sweden
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2021年 / 11卷
基金：
瑞典研究理事会;
关键词：
Streptococcus pneumoniae; pneumococci; influenza virus; COVID-19; respiratory tract infections; coinfection; influenza-pneumococcal coinfection; INFLUENZA-A VIRUSES; PNEUMOCOCCAL PNEUMONIA; BACTERIAL PNEUMONIA; SIALIC ACIDS; ANTIMICROBIAL RESISTANCE; PANDEMIC INFLUENZA; LUNG INFLAMMATION; BIOFILM FORMATION; INVASIVE DISEASE; LETHAL SYNERGISM;
D O I：
10.3389/fcimb.2021.643326
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Secondary bacterial infections enhance the disease burden of influenza infections substantially. Streptococcus pneumoniae (the pneumococcus) plays a major role in the synergism between bacterial and viral pathogens, which is based on complex interactions between the pathogen and the host immune response. Here, we discuss mechanisms that drive the pathogenesis of a secondary pneumococcal infection after an influenza infection with a focus on how pneumococci senses and adapts to the influenza-modified environment. We briefly summarize what is known regarding secondary bacterial infection in relation to COVID-19 and highlight the need to improve our current strategies to prevent and treat viral bacterial coinfections.
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页数：16
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