Relationship between plasma concentrations of cytokine modulators and multiple organ failure in acute pancreatitis

被引：0
|
作者：
Ogawa, M [1 ]
Hirota, M [1 ]
Nozawa, F [1 ]
Okabe, A [1 ]
Shibata, M [1 ]
Kuwata, K [1 ]
机构：
[1] Kumamoto Univ, Sch Med, Dept Surg 2, Kumamoto 860, Japan
来源：
5TH WORLD CONGRESS ON TRAUMA, SHOCK, INFLAMMATION AND SEPSIS: PATHOPHYSIOLOGY, IMMUNE CONSEQUENCES AND THERAPY | 2000年
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D O I：
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中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Plasma concentrations of cytokines and their modulators in patients with acute pancreatitis were analyzed. Those of soluble TNF receptors (sTNF-RI. and sTNF-RII) were significantly higher in patients with multiple organ failure (MOF) than in those without, even upon admission. Plasma concentrations of soluble TNF receptors and IL-1 receptor antagonist were much higher than those of their counterparts, TNF alpha and IL-1 beta, respectively. These results suggest that the plasma concentrations of soluble TNF receptors are useful predictors for the development of MOF, and that actions of TNF alpha and IL-1 beta could be regulated by their modulators in the pathologic condition of severe acute pancreatitis.
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页码：575 / 578
页数：4
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