The intraoperative management of the high-risk patient has received a great deal of attention and research during the past decade. Based on the available evidence, there appears to be no one best anesthetic technique or agent. More importantly, the goals of intraoperative management are to avoid myocardial ischemia, which include preventing tachycardia, and maintaining normothermia and adequate hematocrit. Perioperative monitoring includes transesophageal echocardiography, pulmonary artery catheter and ST segment monitoring. Perioperative pharmacological treatment with α-2 agonists and β-adrenergic blocking agents are associated with a reduced incidence of perioperative myocardial ischemia and improved long-term survival, respectively. Future research will be required to determine whether prophylactic therapy or early treatment of perioperative myocardial ischemia will lead to improved outcome.
机构:
Barnes Jewish Hosp, Dept Pharm, St Louis, MO USABarnes Jewish Hosp, Dept Pharm, St Louis, MO USA
Maamari, Julie A.
Wolfe, Rachel C.
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Barnes Jewish Hosp, Dept Pharm, St Louis, MO USA
One Barnes Jewish Hosp Plaza, St Louis, MO 63110 USABarnes Jewish Hosp, Dept Pharm, St Louis, MO USA
机构:
Univ Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA
MVM Hlth, Pain Med, East Stroudsburg, PA USA
Univ Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA 17701 USAUniv Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA
Orhurhu, Vwaire
Hussain, Nasir
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Ohio State Univ Wexner Med Ctr, Dept Anesthesiol, Columbus, OH USAUniv Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA
Hussain, Nasir
Karri, Jay
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Baylor Coll Med, Phys Med & Rehabil, Houston, TX USAUniv Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA
Karri, Jay
Mariano, Edward R.
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VA Palo Alto Hlth Care Syst, Anesthesiol & Perioperat Care Serv, Palo Alto, CA USA
Stanford Univ Sch Med, Dept Anesthesiol Perioperat & Pain Med, Stanford, CA USAUniv Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA
Mariano, Edward R.
Abd-Elsayed, Alaa
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Univ Wisconsin Madison, Dept Anesthesia, Divs Pain Med, Sch Med & Publ Hlth, Madison, WI USAUniv Pittsburgh Med Ctr, Anesthesiol, Williamsport, PA USA