Model pharmaceutical co-crystallization: Guest-directed assembly of caffeine and aromatic tri-hydroxy and dicarboxylic acids into different heteromolecular hydrogen bonding networks in solid state

被引：15

作者：

Mahapatra, Ajit Kumar ^{[1
]}

Sahoo, Prithidipa ^{[1
]}

Goswami, Shyamaprosad ^{[1
]}

Fun, Hoong-Kun ^{[2
]}

机构：

[1] Bengal Engn & Sci Univ, Dept Chem, Sibpur 711103, Howrah, India

[2] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, Usm 11800, Penang, Malaysia

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2010年 / 963卷 / 01期

关键词：

Pharmaceutical co-crystals; Caffeine; Phloroglucinol; Isophthalic acid; 5-Hydroxyisopthalic acid; Hydrogen bonding; CRYSTAL-STRUCTURES; RECOGNITION; COMPLEX; RECEPTORS; SPECTRA;

D O I：

10.1016/j.molstruc.2009.10.015

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Three model pharmaceutical caffeine-containing co-crystals of 1,3,5-trihydroxybenzene (phloroglucinol), isophthalic acid and 5-hydroxyisophthalic acid were synthesized and characterized via single-crystal X-ray diffraction. The three crystalline forms reported are an anhydrous co-crystal and other two are co-crystal hydrates. Also their binding properties were studied by UV-vis analysis. In each of these structures, an organised intermolecular hydrogen bonding motif was observed. A comparison of hydrogen bonding motifs in the crystal sheets was presented. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：63 / 70

页数：8