Endocrine Role of Stomach in Appetite Regulation in Chronic Kidney Disease: About Ghrelin and Obestatin

被引:6
|
作者
Mafra, Denise [3 ]
Guebre-Egziabher, Fitsum [1 ,2 ]
Fouque, Denis [1 ,2 ]
机构
[1] Hop Edouard Herriot, Dept Nephrol, F-69437 Lyon 03, France
[2] Univ Lyon 1, INSERM, U870, F-69365 Lyon, France
[3] Univ Fed Fluminense, Dept Clin Nutr, Nutr Fac, Niteroi, RJ, Brazil
关键词
CHRONIC-RENAL-FAILURE; PLASMA GHRELIN; FOOD-INTAKE; HORMONE; HEMODIALYSIS; PEPTIDE; SECRETION; LEPTIN; WEIGHT;
D O I
10.1053/j.jrn.2009.08.002
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The stomach may play an important role in central feeding regulation because it produces two peptides, ghrelin and the recently identified obestatin. These peptide hormones exert opposite actions on weight regulation. Whereas ghrelin is orexigenic, obestatin seems to be anorexigenic. Studies on feeding regulation are of particular importance for patients with chronic kidney disease (CKD), because anorexia and weight loss are associated with wasting and increased morbidity and mortality. This review discusses recent information about ghrelin and obestatin and their potential role in CKD. In addition, it seems important to consider not only single values but also their ratios, because both compounds could be affected disharmoniously by CKD. (C) 2010 by the National Kidney Foundation, Inc. All rights reserved.
引用
收藏
页码:68 / 73
页数:6
相关论文
共 50 条
  • [1] Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Inui, A
    Asakawa, A
    Bowers, CY
    Mantovani, G
    Laviano, A
    Meguid, MM
    Fujimiya, M
    FASEB JOURNAL, 2004, 18 (03): : 439 - 456
  • [2] Obestatin/Ghrelin Cells in Normal Mucosa and Endocrine Tumors of the Stomach
    Tsolakis, A.
    Grimelius, L.
    Stridsberg, M.
    Falkmer, S.
    Waldum, H.
    Saras, J.
    Janson, E.
    NEUROENDOCRINOLOGY, 2009, 90 (01) : 139 - 139
  • [3] Obestatin/ghrelin cells in normal mucosa and endocrine tumours of the stomach
    Tsolakis, Apostolos V.
    Grimelius, Lars
    Stridsberg, Mats
    Falkmer, Sture E.
    Waldum, Helge L.
    Saras, Jan
    Janson, Eva T.
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2009, 160 (06) : 941 - 949
  • [4] PLASMA ACYLATED GHRELIN, OBESTATIN AND LEPTIN IN DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE PATIENTS
    Oner-Iyidogan, Yildiz
    Oner, Pernur
    Gurdol, Figen
    Kocak, Hikmet
    Cetinalp-Demircan, Pinar
    Caliskan, Yasar
    Kocak, Taner
    Turkmen, Aydin
    IUBMB LIFE, 2009, 61 (03) : 343 - 343
  • [5] Acyl-Ghrelin and Obestatin Plasma Levels in Different Stages of Chronic Kidney Disease
    Borges, Natalia
    Moraes, Cristiane
    Barros, Amanda F.
    Carraro-Eduardo, Jose C.
    Fouque, Denis
    Mafra, Denise
    JOURNAL OF RENAL NUTRITION, 2014, 24 (02) : 100 - 104
  • [6] ROLE OF APPETITE HORMONES GHRELIN, OREXIN AND OBESTATIN IN THE MECHANISM OF GASTRIC ULCER HEALING
    Brzozowski, Thomas
    Szlachcic, Alexandra
    Konturek, Peter
    Drozdowicz, Danuta
    Kwiecien, Slawomir
    Konturek, Stanislaw J.
    Pawlik, Wieslaw W.
    JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, 59 : 459 - 459
  • [7] Measurement of Ghrelin as a Marker of Appetite Dysregulation in Cats with and without Chronic Kidney Disease
    Brusach, Katelyn
    Lorbach, Sarah
    Quimby, Jessica
    Nijveldt, Eline
    Paschall, Rene
    Kinsella, Hannah
    Parker, Valerie
    Toribio, Ramiro
    VETERINARY SCIENCES, 2023, 10 (07)
  • [8] The role of leptin and ghrelin in the regulation of appetite in obesity
    Skoracka, Kinga
    Hryhorowicz, Szymon
    Schulz, Piotr
    Zawada, Agnieszka
    Ratajczak-Pawlowska, Alicja Ewa
    Rychter, Anna Maria
    Slomski, Ryszard
    Dobrowolska, Agnieszka
    Krela-Kazmierczak, Iwona
    PEPTIDES, 2025, 186
  • [9] Studies question role of ghrelin in appetite regulation
    不详
    GASTROENTEROLOGY, 2004, 127 (02) : 374 - 375
  • [10] Unacylated ghrelin and obestatin: promising biomarkers of protein energy wasting in children with chronic kidney disease
    Monzani, Alice
    Perrone, Michela
    Prodam, Flavia
    Moia, Stefania
    Genoni, Giulia
    Testa, Sara
    Paglialonga, Fabio
    Rapa, Anna
    Bona, Gianni
    Montini, Giovanni
    Edefonti, Alberto
    PEDIATRIC NEPHROLOGY, 2018, 33 (04) : 661 - 672