Synthesis of enantiomerically pure alcohols and amines via biocatalytic deracemisation methods

被引：2

作者：

Musa, Musa M. ^{[1
]}

Hollmann, Frank ^{[2
]}

Mutti, Francesco G. ^{[3
]}

机构：

[1] King Fahd Univ Petr & Minerals, Dept Chem, Dhahran 31261, Saudi Arabia

[2] Delft Univ Technol, Dept Biotechnol, Maasweg 9, NL-2629 HZ Delft, Netherlands

[3] Univ Amsterdam, HIMS Biocat, Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands

来源：

CATALYSIS SCIENCE & TECHNOLOGY | 2019年 / 9卷 / 20期

基金：

欧洲研究理事会;

关键词：

DYNAMIC KINETIC RESOLUTION; ONE-POT DERACEMIZATION; P-NITROSTYRENE OXIDE; SECONDARY ALCOHOLS; EPOXIDE HYDROLASE; ENANTIOCONVERGENT HYDROLYSIS; DIRECTED EVOLUTION; STYRENE OXIDE; IN-VITRO; CHEMOENZYMATIC DERACEMIZATION;

D O I：

10.1039/c9cy01539f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Deracemisation via chemo-enzymatic or multi-enzymatic approaches is the optimum substitute for kinetic resolution, which suffers from the limitation of a theoretical maximum 50% yield albeit high enantiomeric excess is attainable. This review covers the recent progress in various deracemisation approaches applied to the synthesis of enantiomerically pure alcohols and amines, such as (1) dynamic kinetic resolution, (2) cyclic deracemisation, (3) linear deracemisation (including stereoinversion) and (4) enantioconvergent methods.

引用

页码：5487 / 5503

页数：17

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